Mannosyl-oligosaccharide 1,2-alpha-mannosidase explained
| Mannosyl-oligosaccharide 1,2-α-mannosidase |
| Ec Number: | 3.2.1.113 |
| Cas Number: | 9068-25-1 |
Mannosyl-oligosaccharide 1,2-α-mannosidase (mannosidase 1A, mannosidase 1B, 1,2-α-mannosidase, exo-α-1,2-mannanase, mannose-9 processing α-mannosidase, glycoprotein processing mannosidase I, mannosidase I, Man9-mannosidase, ManI, 1,2-α-mannosyl-oligosaccharide α-D-mannohydrolase) is an enzyme with systematic name 2-α-mannosyl-oligosaccharide α-D-mannohydrolase.[1] [2] It catalyses the hydrolysis of the terminal (1→2)-linked α-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2.
This enzyme is involved in the synthesis of glycoproteins.
Kifunensine is a potent inhibitor of mannosidase I.
Notes and References
- Tabas I, Kornfeld S . Purification and characterization of a rat liver Golgi α-mannosidase capable of processing asparagine-linked oligosaccharides . The Journal of Biological Chemistry . 254 . 22 . 11655–63 . November 1979 . 500665. 10.1016/s0021-9258(19)86534-1 . free .
- Tulsiani DR, Hubbard SC, Robbins PW, Touster O . α-D-Mannosidases of rat liver Golgi membranes: Mannosidase II is the GlcNAcMAN5-cleaving enzyme in glycoprotein biosynthesis and mannosidases IA and IB are the enzymes converting Man9 precursors to Man5 intermediates . The Journal of Biological Chemistry . 257 . 7 . 3660–8 . April 1982 . 7061502 . Oscar Touster. 10.1016/s0021-9258(18)34831-2 . free .
