Mannan-binding lectin-associated serine protease-2 explained

Mannan-binding lectin-associated serine protease-2
Ec Number:3.4.21.104
Cas Number:214915-16-9

Mannan-binding lectin-associated serine protease-2 (MASP-2, MASP2, MBP-associated serine protease-2, mannose-binding lectin-associated serine protease-2, p100, mannan-binding lectin-associated serine peptidase 2) is an enzyme.[1] [2] [3] [4] [5] [6] [7] This enzyme catalyses the following chemical reaction

Selective cleavage after Arg223 in complement component C2 (-Ser-Leu-Gly-Arg-Lys-Ile-Gln-Ile) and after Arg76 in complement component C4 (-Gly-Leu-Gln-Arg-Ala-Leu-Glu-Ile)

This mannan-binding lectin (MBL) recognizes patterns of neutral carbohydrates, such as mannose and N-acetylglucosamine.

Notes and References

  1. Matsushita M, Fujita T . Activation of the classical complement pathway by mannose-binding protein in association with a novel C1s-like serine protease . The Journal of Experimental Medicine . 176 . 6 . 1497–502 . December 1992 . 1460414 . 2119445 . 10.1084/jem.176.6.1497 .
  2. Thiel S, Vorup-Jensen T, Stover CM, Schwaeble W, Laursen SB, Poulsen K, Willis AC, Eggleton P, Hansen S, Holmskov U, Reid KB, Jensenius JC . A second serine protease associated with mannan-binding lectin that activates complement . Nature . 386 . 6624 . 506–10 . April 1997 . 9087411 . 10.1038/386506a0 .
  3. Rossi V, Cseh S, Bally I, Thielens NM, Jensenius JC, Arlaud GJ . Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2 . The Journal of Biological Chemistry . 276 . 44 . 40880–7 . November 2001 . 11527969 . 10.1074/jbc.M105934200 . free .
  4. Ambrus G, Gál P, Kojima M, Szilágyi K, Balczer J, Antal J, Gráf L, Laich A, Moffatt BE, Schwaeble W, Sim RB, Závodszky P . Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: a study on recombinant catalytic fragments . Journal of Immunology . 170 . 3 . 1374–82 . February 2003 . 12538697 . 10.4049/jimmunol.170.3.1374 . free .
  5. Harmat V, Gál P, Kardos J, Szilágyi K, Ambrus G, Végh B, Náray-Szabó G, Závodszky P . The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions . Journal of Molecular Biology . 342 . 5 . 1533–46 . October 2004 . 15364579 . 10.1016/j.jmb.2004.07.014 .
  6. Chen CB, Wallis R . Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases . The Journal of Biological Chemistry . 279 . 25 . 26058–65 . June 2004 . 15060079 . 10.1074/jbc.M401318200 . free .
  7. Teillet F, Dublet B, Andrieu JP, Gaboriaud C, Arlaud GJ, Thielens NM . The two major oligomeric forms of human mannan-binding lectin: chemical characterization, carbohydrate-binding properties, and interaction with MBL-associated serine proteases . Journal of Immunology . 174 . 5 . 2870–7 . March 2005 . 15728497 . 10.4049/jimmunol.174.5.2870 . free .

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