Mammalian CPEB3 ribozyme explained

Mammalian CPEB3 ribozyme
Symbol:CPEB3_ribozyme
Rfam:RF00622
Rna Type:Gene
ribozyme
Tax Domain:Eukaryota

The mammalian CPEB3 ribozyme is a self cleaving non-coding RNA located in the second intron of the CPEB3 gene which belongs to a family of genes regulating messenger RNA polyadenylation.[1] This ribozyme is highly conserved andfound only in mammals. The CPEB3 ribozyme is structurally and biochemically related to the human hepatitis delta virus ribozyme.[2] Other HDV-like ribozymes have been identified and confirmed to be active in vitro in a number of eukaryotes.[3]

Notes and References

  1. Salehi-Ashtiani K, Luptak A, Litovchick A, Szostak JW . A genomewide search for ribozymes reveals an HDV-like sequence in thehuman CPEB3 gene. . Science . 313 . 5794. 1788–1792 . 2006 . 16990549 . 10.1126/science.1129308. 2006Sci...313.1788S . 43309772 .
  2. Chadalavada DM, Gratton EA, Bevilacqua PC . The Human HDV-like CPEB3 Ribozyme Is Intrinsically Fast-Reacting. . Biochemistry . 49. 25. 5321–5330. 2010 . 20524672 . 2890282 . 10.1021/bi100434c.
  3. Webb. CH . Riccitelli, NJ . Ruminski, DJ . Lupták, A. Widespread occurrence of self-cleaving ribozymes.. Science. Nov 13, 2009. 326. 5955. 953. 19965505. 10.1126/science.1178084. 3159031. 2009Sci...326..953W .

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