Malouetine Explained

Malouetine is an aminosteroid neuromuscular blocking agent and antinicotinic alkaloid isolated from Malouetia spp.^[1]

The structure of malouetine inspired the development of modern aminosteroid muscle relaxants such as pancuronium bromide and vecuronium bromide by workers at Organon.^{[2] [3] [4]}

Notes and References

1. 13789457 . 1960 . Janot MM . Laine F . Goutarel R . Steroid alkaloids. V. Alkaloids of Malouetia bequaertiana e. Woodson (Apocynaceae): Funtuphyllamine B and malouetine. Preliminary communication . Annales Pharmaceutiques Françaises . 18 . 673–677 .
2. Alauddin . M. . Caddy . B. . Lewis . J.J. . Martin-Smith . M. . Sugrue . M.F. . Non-depolarising neuromuscular blockade by 3α,17α-bis(quaternary ammonium) 5α-androstanes . Journal of Pharmacy and Pharmacology . January 1965 . 17 . 1 . 55–59 . 10.1111/j.2042-7158.1965.tb07569.x. 14285698 . 71497007 .
3. Buckett . W.R. . Hewett . C.L. . Savage . D.S. . Pancuronium bromide and other steroidal neuromuscular blocking agents containing acetylcholine fragments . Journal of Medicinal Chemistry . October 1973 . 16 . 10 . 1116–24 . 10.1021/jm00268a011 . 4356139.
4. McKenzie . A.G. . Prelude to pancuronium and vecuronium . Anaesthesia . June 2000 . 55 . 6 . 551–556 . 10.1046/j.1365-2044.2000.01423.x. 10866718 . 22476701 .