Malonyl CoA reductase (malonate semialdehyde-forming) explained

Malonyl CoA reductase (malonate semialdehyde-forming)
Ec Number:	1.2.1.75

Malonyl CoA reductase (malonate semialdehyde-forming) (NADP-dependent malonyl CoA reductase, malonyl CoA reductase (NADP)) is an enzyme with systematic name malonate semialdehyde:NADP⁺ oxidoreductase (malonate semialdehyde-forming).^{[1] [2] [3] [4]} This enzyme catalyse the following chemical reaction

malonate semialdehyde + CoA + NADP⁺

\rightleftharpoons malonyl-CoA + NADPH + H⁺

Requires Mg²⁺. Catalyses the reduction of malonyl-CoA to malonate semialdehyde.

Notes and References

1. Strauss G, Fuchs G . Enzymes of a novel autotrophic CO2 fixation pathway in the phototrophic bacterium Chloroflexus aurantiacus, the 3-hydroxypropionate cycle . European Journal of Biochemistry . 215 . 3 . 633–43 . August 1993 . 8354269 . 10.1111/j.1432-1033.1993.tb18074.x . free .
2. Berg IA, Kockelkorn D, Buckel W, Fuchs G . A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea . Science . 318 . 5857 . 1782–6 . December 2007 . 18079405 . 10.1126/science.1149976 .
3. Alber B, Olinger M, Rieder A, Kockelkorn D, Jobst B, Hügler M, Fuchs G . Malonyl-coenzyme A reductase in the modified 3-hydroxypropionate cycle for autotrophic carbon fixation in archaeal Metallosphaera and Sulfolobus spp . Journal of Bacteriology . 188 . 24 . 8551–9 . December 2006 . 17041055 . 1698253 . 10.1128/JB.00987-06 .
4. Hügler M, Menendez C, Schägger H, Fuchs G . Malonyl-coenzyme A reductase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO(2) fixation . Journal of Bacteriology . 184 . 9 . 2404–10 . May 2002 . 11948153 . 134993 . 10.1128/jb.184.9.2404-2410.2002 .