Malonate-semialdehyde dehydrogenase (acetylating) explained

malonate-semialdehyde dehydrogenase (acetylating)
Ec Number:	1.2.1.18
Cas Number:	9028-97-1
Go Code:	0018478

In enzymology, a malonate-semialdehyde dehydrogenase (acetylating) is an enzyme that catalyzes the chemical reaction

3-oxopropanoate + CoA + NAD(P)+

\rightleftharpoons acetyl-CoA + CO₂ + NAD(P)H

The 4 substrates of this enzyme are 3-oxopropanoate, CoA, NAD⁺, and NADP⁺, whereas its 4 products are acetyl-CoA, CO₂, NADH, and NADPH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-oxopropanoate:NAD(P)+ oxidoreductase (decarboxylating, CoA-acetylating). This enzyme is also called malonic semialdehyde oxidative decarboxylase. This enzyme participates in 4 metabolic pathways: inositol metabolism, alanine and aspartate metabolism, beta-alanine metabolism, and propanoate metabolism.

Further reading

• Hayaishi O, Nishizuka Y, Tatibana M, Takeshita M, Kuno S . Enzymatic studies on the metabolism of beta-alanine . The Journal of Biological Chemistry . 236 . 781–90 . March 1961 . 13712439 .
• Yamada EW, Jakoby WB . Aldehyde oxidation. V. Direct conversion of malonic semialdehyde to acetyl-coenzyme A . The Journal of Biological Chemistry . 235 . 589–94 . March 1960 . 13846369 .
• Book: Jakoby WB . Aldehyde dehydrogenase . Boyer PD, Lardy H, Myrback K . The Enzymes . 2nd . 7 . Academic Press . New York . 1963 . 203–221 .