Malate dehydrogenase (quinone) explained

malate dehydrogenase (quinone)
Ec Number:	1.1.5.4
Cas Number:	71822-24-7
Go Code:	0052589

In enzymology, a malate dehydrogenase (quinone), formerly malate dehydrogenase (acceptor) (EC 1.1.99.16), is an enzyme that catalyzes the chemical reaction

(S)-malate + a quinone

\rightleftharpoons oxaloacetate + reduced quinone

Thus, the two substrates of this enzyme are (S)-malate and a quinone, whereas its two products are oxaloacetate and reduced quinone.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with a quinone as acceptor. The systematic name of this enzyme class is (S)-malate:quinone oxidoreductase. Other names in common use include FAD-dependent malate-vitamin K reductase, malate-vitamin K reductase, and (S)-malate:(quinone) oxidoreductase. This enzyme participates in pyruvate metabolism. It employs one cofactor, FAD.

References

• Imai D . Brodie AF . 1973 . A phospholipid-requiring enzyme, malate-vitamin K reductase . J. Biol. Chem. . 248 . 21 . 7487 - 7494 . 10.1016/S0021-9258(19)43316-4 . free .
• Imai T . 1978 . FAD-dependent malate dehydrogenase, a phospholipid-requiring enzyme from Mycobacterium sp. strain Takeo. Purification and some properties . Biochim. Biophys. Acta . 523 . 37 - 46 . 629992 . 1 . 10.1016/0005-2744(78)90006-2.
• Prasada Reddy TL, Suryanarayana Murthy P, Venkitasubramanian TA . 1975 . Variations in the pathways of malate oxidation and phosphorylation in different species of Mycobacteria . Biochim. Biophys. Acta . 376 . 210 - 8 . 234747 . 2 . 10.1016/0005-2728(75)90012-2.