Malate dehydrogenase (oxaloacetate-decarboxylating) explained

malate dehydrogenase (oxaloacetate-decarboxylating)
Ec Number:	1.1.1.38
Cas Number:	9080-52-8
Go Code:	0016619

In enzymology, a malate dehydrogenase (oxaloacetate-decarboxylating) is an enzyme that catalyzes the chemical reaction below

(S)-malate + NAD⁺

\rightleftharpoons pyruvate + CO₂ + NADH

Thus, the two substrates of this enzyme are (S)-malate and NAD⁺, whereas its 3 products are pyruvate, CO₂, and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (S)-malate:NAD⁺ oxidoreductase (oxaloacetate-decarboxylating). Other names in common use include malic enzyme, pyruvic-malic carboxylase, NAD⁺-specific malic enzyme, NAD⁺-malic enzyme, and NAD⁺-linked malic enzyme. This enzyme participates in pyruvate metabolism.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes,,,,,,,,,,,, and .

See also

• ME2 (gene)

References

• Kaufman S, Korkes S, Del Campillo A . 1951 . Biosynthesis of dicarboxylic acids by carbon dioxide fixation. V Further studies of the "malic" enzyme of Lactobacillus arabinosus . J. Biol. Chem. . 192 . 301–312 . 14917678 .