Malate dehydrogenase (NAD(P)+) explained

Malate dehydrogenase (NAD(P)+)
Ec Number:1.1.1.299

Malate dehydrogenase (NAD(P)+) (MdH II, NAD(P)+-dependent malate dehyrogenase) is an enzyme with systematic name (S)-malate:NAD(P)+ oxidoreductase.[1] This enzyme catalyses the following chemical reaction

(S)-malate + NAD(P)+

\rightleftharpoons

oxaloacetate + NAD(P)H + H+

This enzyme, which was characterized from the methanogenic archaeon Methanobacterium thermoautotrophicum, catalyses only the reduction of oxaloacetate, and can use NAD+ and NADP+ with similar specific activity. It is different from EC 1.1.1.37 (malate dehydrogenase (NAD+)), EC 1.1.1.82 (malate dehydrogenase (NADP+)) and EC 1.1.5.4 (malate dehydrogenase (quinone)).

Notes and References

  1. Thompson H, Tersteegen A, Thauer RK, Hedderich R . Two malate dehydrogenases in Methanobacterium thermoautotrophicum . Archives of Microbiology . 170 . 1 . 38–42 . July 1998 . 9639601 . 10.1007/s002030050612 .

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