Mafosfamide Explained

Mafosfamide (INN) is an oxazaphosphorine (cyclophosphamide-like) alkylating agent under investigation as a chemotherapeutic. It is metabolized by cytochrome P450 into 4-hydroxycyclophosphamide, which is then converted into aldophosphamide, which, in turn yields the cytotoxic metabolites phosphoramide mustard and acrolein.^[1]

Several Phase I trials have been completed.^{[2] [3]}

Notes and References

1. Ludeman SM. The chemistry of the metabolites of cyclophosphamide. Curr Pharm Des. 1999 Aug;5(8):627-43.
2. Web site: Intrathecal Mafosfamide . 2007-07-13 . August 21, 2006 . . ClinicalTrials.gov. ClinicalTrials.gov Identifier NCT00062881.
3. Web site: Mafosfamide in Treating Patients With Progressive or Refractory Meningeal Tumors . 2007-07-13 . February 20, 2007 . . ClinicalTrials.gov. ClinicalTrials.gov Identifier NCT00031928.