Macrophage elastase explained

Macrophage elastase
Ec Number:	3.4.24.65
Cas Number:	2594837

Macrophage elastase (metalloelastase, human macrophage metalloelastase (HME), MMP-12) is an enzyme.^{[1] [2] [3] [4]} This enzyme catalyses the following chemical reaction

Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at -Ala¹⁴-Leu- and -Tyr¹⁶-Leu- in the B chain of insulin

This enzyme belongs to the peptidase family M10.

See also

• Matrix metallopeptidase 12

Notes and References

1. Banda MJ, Werb Z . Mouse macrophage elastase. Purification and characterization as a metalloproteinase . The Biochemical Journal . 193 . 2 . 589–605 . February 1981 . 7030312 .
2. Kettner C, Shaw E, White R, Janoff A . The specificity of macrophage elastase on the insulin B-chain . The Biochemical Journal . 195 . 2 . 369–72 . May 1981 . 7032505 .
3. Shapiro SD, Griffin GL, Gilbert DJ, Jenkins NA, Copeland NG, Welgus HG, Senior RM, Ley TJ . Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase . The Journal of Biological Chemistry . 267 . 7 . 4664–71 . March 1992 . 1537850 .
4. Shapiro SD, Kobayashi DK, Ley TJ . Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages . The Journal of Biological Chemistry . 268 . 32 . 23824–9 . November 1993 . 8226919 .