LysC explained

LysC is a prokaryotic aspartokinase involved in the biosynthesis of the amino acid lysine. It is found in a variety of bacteria, including Bacillus subtilis, Escherichia coli and Corynebacterium glutamicum.[1] It is notable for containing a riboswitch, a structure in its messenger RNA that prevents its translation when bound to lysine.[2] Such lysine riboswitch thus acts as a mechanism of negative feedback.

Notes and References

  1. Grundy. F. J.. Lehman. S. C.. Henkin. T. M.. The L box regulon: Lysine sensing by leader RNAs of bacterial lysine biosynthesis genes. Proceedings of the National Academy of Sciences. 1 October 2003. 100. 21. 12057–12062. 10.1073/pnas.2133705100. 14523230. 218712. 2003PNAS..10012057G. free.
  2. Sudarsan. N.. An mRNA structure in bacteria that controls gene expression by binding lysine. Genes & Development. 16 October 2003. 17. 21. 2688–2697. 10.1101/gad.1140003. 14597663. 280618.

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