Lupanine 17-hydroxylase (cytochrome c) explained

Lupanine 17-hydroxylase (cytochrome c)
Ec Number:1.17.2.2

Lupanine 17-hydroxylase (cytochrome c) (lupanine dehydrogenase (cytochrome c)) is an enzyme with systematic name lupanine:cytochrome c-oxidoreductase (17-hydroxylating).[1] [2] This enzyme catalyses the following chemical reaction

lupanine + 2 ferricytochrome c + H2O

\rightleftharpoons

17-hydroxylupanine + 2 ferrocytochrome c + 2 H+

The enzyme isolated from Pseudomonas putida contains heme c and requires pyrroloquinoline quinone (PQQ) for activity

Notes and References

  1. Hopper DJ, Rogozinski J, Toczko M . Lupanine hydroxylase, a quinocytochrome c from an alkaloid-degrading Pseudomonas sp . The Biochemical Journal . 279 (Pt 1) . 105–9 . October 1991 . 10.1042/bj2790105 . 1656935 . 1151552 .
  2. Hopper DJ, Kaderbhai MA . The quinohaemoprotein lupanine hydroxylase from Pseudomonas putida . Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics . 1647 . 1–2 . 110–5 . April 2003 . 12686118 . 10.1016/s1570-9639(03)00070-0 .

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