Lumefantrine Explained

Lumefantrine (or benflumetol) is an antimalarial drug. It is only used in combination with artemether. The term "co-artemether" is sometimes used to describe this combination.^[1] Lumefantrine has a much longer half-life compared to artemether, and is therefore thought to clear any residual parasites that remain after combination treatment.^[2]

Lumefantrine, along with pyronaridine and naphthoquine, were synthesized during the Chinese Project 523 antimalaria drug research effort initiated in 1967; these compounds are all used in combination antimalaria therapies.^{[3] [4] [5]}

See also

• Artemether/lumefantrine
• Halofantrine

Notes and References

1. Toovey S, Jamieson A, Nettleton G . Successful co-artemether (artemether-lumefantrine) clearance of falciparum malaria in a patient with severe cholera in Mozambique . Travel Medicine and Infectious Disease . 1 . 3 . 177–179 . August 2003 . 17291911 . 10.1016/j.tmaid.2003.09.002 .
2. White NJ, van Vugt M, Ezzet F . Clinical pharmacokinetics and pharmacodynamics and pharmacodynamics of artemether-lumefantrine . Clinical Pharmacokinetics . 37 . 2 . 105–125 . August 1999 . 10496300 . 10.2165/00003088-199937020-00002 . 72714420 .
3. Cui L, Su XZ . Discovery, mechanisms of action and combination therapy of artemisinin . Expert Review of Anti-Infective Therapy . 7 . 8 . 999–1013 . October 2009 . 19803708 . 2778258 . 10.1586/eri.09.68 .
4. Benjamin J, Moore B, Lee ST, Senn M, Griffin S, Lautu D, Salman S, Siba P, Mueller I, Davis TM . 6 . Artemisinin-naphthoquine combination therapy for uncomplicated pediatric malaria: a tolerability, safety, and preliminary efficacy study . Antimicrobial Agents and Chemotherapy . 56 . 5 . 2465–2471 . May 2012 . 22330921 . 3346652 . 10.1128/AAC.06248-11 .
5. Laman M, Moore BR, Benjamin JM, Yadi G, Bona C, Warrel J, Kattenberg JH, Koleala T, Manning L, Kasian B, Robinson LJ, Sambale N, Lorry L, Karl S, Davis WA, Rosanas-Urgell A, Mueller I, Siba PM, Betuela I, Davis TM . 6 . Artemisinin-naphthoquine versus artemether-lumefantrine for uncomplicated malaria in Papua New Guinean children: an open-label randomized trial . PLOS Medicine . 11 . 12 . e1001773 . December 2014 . 25549086 . 4280121 . 10.1371/journal.pmed.1001773 . free .