Low-density-lipoprotein receptor kinase explained

low-density lipoprotein kinase
Ec Number:	2.7.11.29
Cas Number:	107445-00-1
Go Code:	0050063

In enzymology, a low-density-lipoprotein receptor kinase is an enzyme that catalyzes the chemical reaction

ATP + [low-density-lipoprotein receptor]-L-serine

\rightleftharpoons ADP + [low-density-lipoprotein receptor]-O-phospho-L-serine

Thus, the two substrates of this enzyme are ATP and low-density-lipoprotein receptor-L-serine]], whereas its two products are ADP and low-density-lipoprotein receptor-O-phospho-L-serine]].

This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:[low-density-lipoprotein receptor]-L-serine O-phosphotransferase. Other names in common use include ATP:low-density-lipoprotein-L-serine O-phosphotransferase, LDL receptor kinase, [low-density-lipoprotein] kinase, low-density lipoprotein kinase, low-density-lipoprotein receptor kinase (phosphorylating), and STK7.

References

• Kishimoto A, Brown MS, Slaughter CA, Goldstein JL . 1987 . Phosphorylation of serine 833 in cytoplasmic domain of low density lipoprotein receptor by a high molecular weight enzyme resembling casein kinase II . J. Biol. Chem. . 262 . 1344 - 51 . 3100530 . 3 .
• Kishimoto A, Goldstein JL, Brown MS . 1987 . Purification of catalytic subunit of low density lipoprotein receptor kinase and identification of heat-stable activator protein . J. Biol. Chem. . 262 . 9367 - 73 . 3597414 . 19 .