Lovotibeglogene autotemcel explained
| Tradename: | Lyfgenia |
| Dailymedid: | Lovotibeglogene autotemcel |
| Routes Of Administration: | Intravenous |
| Atc Prefix: | None |
| Legal Us: | Rx-only |
| Legal Us Comment: | [1] [2] |
| Drugbank: | DB18680 |
| Unii: | 2C6A9NH2Z8 |
| Kegg: | D12765 |
| Synonyms: | bb1111, lovo-cel, LentiGlobin for sickle cell disease |
Lovotibeglogene autotemcel, sold under the brand name Lyfgenia, is a lentiviral gene therapy used for the treatment of sickle cell disease.[3] [4]
The most common side effects include stomatitis (mouth sores of the lips, mouth, and throat), low levels of platelets, white blood cells, and red blood cells, and febrile neutropenia (fever and low white blood cell count), consistent with chemotherapy and underlying disease.
The US Food and Drug Administration (FDA) approved lovotibeglogene autotemcel in December 2023.[5] [6]
Medical uses
Lovotibeglogene autotemcel is indicated for the treatment of people aged twelve years of age and older with sickle cell disease and a history of vaso-occlusive events.
The recipient's blood stem cells are genetically modified to produce HbA (T87Q), a gene-therapy derived hemoglobin A, which is similar to the normal adult hemoglobin produced in persons not affected by sickle cell disease. Red blood cells containing HbA (T87Q) have a lower risk of sickling and occluding blood flow. These modified stem cells are then delivered to the recipient.
The gene therapy is made from the recipient's own blood stem cells, which are modified, and are given back as a one-time, single-dose infusion as part of a hematopoietic (blood) stem cell transplant. Prior to treatment, the recipient's own stem cells are collected, and then the recipient must undergo myeloablative conditioning (high-dose chemotherapy), a process that removes cells from the bone marrow so they can be replaced with the modified cells in lovotibeglogene autotemcel.
Side effects
The US FDA label contains a black box warning about hematologic malignancy (blood cancer).
History
The safety and effectiveness of lovotibeglogene autotemcel is based on the analysis of data from a single-arm, 24-month multicenter study in participants with sickle cell disease and history of Vaso-occlusive episodes (VOEs) between the ages of twelve and fifty years. Effectiveness was evaluated based on complete resolution of VOEs (VOE-CR) between six and eighteen months after infusion with lovotibeglogene autotemcel. Twenty-eight (88%) of 32 participants achieved VOE-CR during this time period.
The FDA granted the application for lovotibeglogene autotemcel priority review, orphan drug, fast track, and regenerative medicine advanced therapy designations. The FDA granted approval of Lyfgenia to Bluebird Bio Inc.
Society and culture
Economics
The cost effectiveness threshold of the therapy is estimated to be between to $2.05 million.[7]
Brand names
Lovotibeglogene autotemcel is the international nonproprietary name.[8]
Lovotibeglogene autotemcel is sold under the brand name Lyfgenia.
Further reading
- Kanter J, Walters MC, Krishnamurti L, Mapara MY, Kwiatkowski JL, Rifkin-Zenenberg S, Aygun B, Kasow KA, Pierciey FJ, Bonner M, Miller A, Zhang X, Lynch J, Kim D, Ribeil JA, Asmal M, Goyal S, Thompson AA, Tisdale JF . Biologic and Clinical Efficacy of LentiGlobin for Sickle Cell Disease . The New England Journal of Medicine . 386 . 7 . 617–628 . February 2022 . 34898139 . 10.1056/NEJMoa2117175 . free . doi .
External links
Notes and References
- Web site: Lyfgenia- lovotibeglogene autotemcel suspension . DailyMed . 22 December 2023 . 30 December 2023.
- Web site: Lyfgenia . U.S. Food and Drug Administration (FDA) . 8 December 2023 . 9 December 2023 . 8 December 2023 . https://web.archive.org/web/20231208210239/https://www.fda.gov/vaccines-blood-biologics/lyfgenia . live .
- Kanter . Julie . Thompson . Alexis A. . Pierciey . Francis J. . Hsieh . Matthew . Uchida . Naoya . Leboulch . Philippe . Schmidt . Manfred . Bonner . Melissa . Guo . Ruiting . Miller . Alex . Ribeil . Jean-Antoine . Davidson . David . Asmal . Mohammed . Walters . Mark C. . Tisdale . John F. . Lovo-cel gene therapy for sickle cell disease: Treatment process evolution and outcomes in the initial groups of the HGB -206 study . American Journal of Hematology . January 2023 . 98 . 1 . 11–22 . 10.1002/ajh.26741. 36161320 . 10092845 . 252544370 . free .
- Sheridan . Cormac . The world's first CRISPR therapy is approved: who will receive it? . Nature Biotechnology . 21 November 2023 . 42 . 1 . 3–4 . 10.1038/d41587-023-00016-6 . 37989785 . 265350318 . 4 December 2023 . 4 December 2023 . https://web.archive.org/web/20231204182913/https://www.nature.com/articles/d41587-023-00016-6 . live .
- Web site: FDA Approves First Gene Therapies to Treat Patients with Sickle Cell Disease . U.S. Food and Drug Administration (FDA) . 8 December 2023 . 8 December 2023 . 8 December 2023 . https://web.archive.org/web/20231208165916/https://www.fda.gov/news-events/press-announcements/fda-approves-first-gene-therapies-treat-patients-sickle-cell-disease . live .
- Bluebird Bio Announces FDA Approval of Lyfgenia (lovotibeglogene autotemcel) for Patients Ages 12 and Older with Sickle Cell Disease and a History of Vaso-Occlusive Events . Bluebird Bio . Business Wire . 8 December 2023 . 9 December 2023.
- Web site: ICER Publishes Final Evidence Report on Gene Therapies for Sickle Cell Disease . . 4 December 2023 . 4 December 2023 . https://web.archive.org/web/20231204221956/https://icer.org/news-insights/press-releases/icer-publishes-final-evidence-report-on-gene-therapies-for-sickle-cell-disease/ . live .
- ((World Health Organization)) . 2022 . International nonproprietary names for pharmaceutical substances (INN): recommended INN: list 87 . WHO Drug Information . 36 . 1 . 10665/352794 . free . World Health Organization .
