Lofendazam Explained

Lofendazam^[1] is an organic molecule which is a benzodiazepine derivative. Lofendazam is a 1,5-benzodiazepine, with the nitrogen atoms located at positions 1 and 5 of the diazepine ring; therefore, lofendazam is most closely related to other 1,5-benzodiazepines such as clobazam.^{[2] [3]}

Lofendazam as a human pharmaceutical has sedative and anxiolytic effects similar to those produced by other benzodiazepine derivatives. It is an active metabolite of another benzodiazepine, arfendazam.^[4]

See also

• Benzodiazepine
• Arfendazam
• Clobazam

Notes and References

1. DE . 1929656 .
2. Malik F, Hasan M, Khan KM, Perveen S, Snatzke G, Duddeck H, Voelter W . Syntheses and CD studies of optically active substituted 1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-ones. . Liebigs Annalen der Chemie . 1995 . 1995 . 10 . 1861–1869 . 10.1002/jlac.1995199510261 .
3. Aversa MC, Giannetto P, Romeo G, Ficarra P, Vigorita MG . Nuclear magnetic resonance spectra of psychotherapeutic agents. V* - conformational analysis of 1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-ones. . Organic Magnetic Resonance . 1981 . 15 . 4 . 394–398 . 10.1002/mrc.1270150414 .
4. Book: Adrien J, Albani F, Baruzzi A, Berger M, Bixler EO, Borbeley AA, Dikeos DG, Drucker-Colin R, Montero RF, Hishikawa Y, Inoue S . The Pharmacology of Sleep . 11 December 1995 . Springer . 978-3-540-58961-7 .