Locus suicide recombination explained

Locus suicide recombination (LSR) constitutes a variant form of class switch recombination that eliminates all immunoglobulin heavy chain constant genes.^[1] It thus terminates immunoglobulin and B-cell receptor (BCR) expression in B-lymphocytes and results in B-cell death since survival of such cells requires BCR expression. This process is initiated by the enzyme activation-induced deaminase upon B-cell activation. LSR is thus one of the pathways that can result into activation-induced cell death in the B-cell lineage.^[2]

References

1. Book: Acton, Q.A. . Immunoglobulins—Advances in Research and Application: 2013 Edition . ScholarlyEditions . 2013 . 978-1-4816-8886-4 . 26 October 2018 . 866.
2. Peron . S. . Laffleur . B. . Denis-Lagache . N. . Cook-Moreau . J. . Tinguely . A. . Delpy . L. . Denizot . Y. . Pinaud . E. . Cogne . M. . AID-Driven Deletion Causes Immunoglobulin Heavy Chain Locus Suicide Recombination in B Cells . Science . American Association for the Advancement of Science (AAAS) . 336 . 6083 . 26 April 2012 . 0036-8075 . 22539552 . 10.1126/science.1218692 . 931–934. 2012Sci...336..931P . 1513560 .