Liquiritigenin Explained

Liquiritigenin is a flavanone that was isolated from Glycyrrhiza uralensis, and is found in a variety of plants of the Glycyrrhiza genus, including Glycyrrhiza glabra (licorice).^[1] It is an estrogenic compound which acts as a selective agonist of the ERβ subtype of the estrogen receptor (ER),^[2] though it is also reported to act as an ERα partial agonist at sufficient concentrations. It also has a choleretic effect.^[1]

is an enzyme that uses liquiritigenin, O₂, NADPH and H⁺ to produce 2,7,4'-trihydroxyisoflavanone, H₂O, and NADP⁺.

See also

• Menerba
• Prinaberel (ERB-041)
• Diarylpropionitrile (DPN)
• WAY-200070
• PHTPP
• (R,R)-Tetrahydrochrysene ((R,R)-THC)
• Propylpyrazoletriol (PPT)
• Methylpiperidinopyrazole (MPP)

Notes and References

1. 19074639 . 2009 . Kim . YW . Kang . HE . Lee . MG . Hwang . SJ . Kim . SC . Lee . CH . Kim . SG . Liquiritigenin, a flavonoid aglycone from licorice, has a choleretic effect and the ability to induce hepatic transporters and phase-II enzymes . 296 . 2 . G372–81 . 10.1152/ajpgi.90524.2008 . American Journal of Physiology. Gastrointestinal and Liver Physiology.
2. 10.1016/j.mce.2007.11.020 . Liquiritigenin is a plant-derived highly selective estrogen receptor β agonist . 2008 . Mersereau . Jennifer E. . Levy . Nitzan . Staub . Richard E. . Baggett . Scott . Zogric . Tetjana . Chow . Sylvia . Ricke . William A. . Tagliaferri . Mary . Cohen . Isaac . Bjeldanes . Leonard F. . Leitman . D. C. . Molecular and Cellular Endocrinology . 283 . 49–57 . 18177995 . 1–2 . 2277338. 8 .