Liprin-alpha-1 explained

Liprin-alpha-1 is a protein that in humans is encoded by the PPFIA1 gene.^{[1] [2] [3]}

Function

The protein encoded by this gene is a member of the LAR protein tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described.^[3]

Interactions

Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 has been shown to interact with:

• ERC2,
• GIT1,
• GRIP2,^{[4] [5]}
• PPFIBP1,^[2]
• PPP2R5D,^[6]
• PTPRD,
• PTPRF,^[7] and
• PTPRS.^{[2] [7]}

Further reading

• Pulido R, Serra-Pagès C, Tang M, Streuli M . The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1. . Proc. Natl. Acad. Sci. U.S.A. . 92 . 25 . 11686–11690 . 1996 . 8524829 . 40467 . 10.1073/pnas.92.25.11686 . 1995PNAS...9211686P . free .
• Wyszynski M, Kim E, Dunah AW, Passafaro M, Valtschanoff JG, Serra-Pagès C, Streuli M, Weinberg RJ, Sheng M . Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting. . Neuron . 34 . 1 . 39–52 . 2002 . 11931740 . 10.1016/S0896-6273(02)00640-2 . free .
• Ko J, Kim S, Valtschanoff JG, Shin H, Lee JR, Sheng M, Premont RT, Weinberg RJ, Kim E . Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting. . J. Neurosci. . 23 . 5 . 1667–1677 . 2003 . 12629171 . 10.1523/JNEUROSCI.23-05-01667.2003. 6741975 . free .
• Ko J, Na M, Kim S, Lee JR, Kim E . Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins. . J. Biol. Chem. . 278 . 43 . 42377–42385 . 2004 . 12923177 . 10.1074/jbc.M307561200 . free .
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T . Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. . Curr. Biol. . 14 . 16 . 1436–1450 . 2004 . 15324660 . 10.1016/j.cub.2004.07.051 . free . 2004CBio...14.1436J .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–1178 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Serra-Pagès C, Streuli M, Medley QG . Liprin phosphorylation regulates binding to LAR: evidence for liprin autophosphorylation. . Biochemistry . 44 . 48 . 15715–15724 . 2006 . 16313174 . 2529169 . 10.1021/bi051434f .
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. . Cell . 125 . 4 . 801–814 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . free .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–648 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . free .
• Casper Hoogenraad . Hoogenraad CC, Feliu-Mojer MI, Spangler SA, Milstein AD, Dunah AW, Hung AY, Sheng M . Liprinalpha1 degradation by calcium/calmodulin-dependent protein kinase II regulates LAR receptor tyrosine phosphatase distribution and dendrite development. . Dev. Cell . 12 . 4 . 587–602 . 2007 . 17419996 . 10.1016/j.devcel.2007.02.006 . free .

Notes and References

1. Serra-Pagès C, Kedersha NL, Fazikas L, Medley Q, Debant A, Streuli M . The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions . EMBO J . 14 . 12 . 2827–2838 . Aug 1995 . 7796809 . 398401 . 10.1002/j.1460-2075.1995.tb07282.x.
2. Serra-Pagès C, Medley QG, Tang M, Hart A, Streuli M . Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins . J Biol Chem . 273 . 25 . 15611–15620 . Jul 1998 . 9624153 . 10.1074/jbc.273.25.15611 . free .
3. Web site: Entrez Gene: PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1.
4. Ko J, Na M, Kim S, Lee JR, Kim E . Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins . J. Biol. Chem. . 278 . 43 . 42377–85 . Oct 2003 . 12923177 . 10.1074/jbc.M307561200 . free .
5. Ko J, Kim S, Valtschanoff JG, Shin H, Lee JR, Sheng M, Premont RT, Weinberg RJ, Kim E . Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting . J. Neurosci. . 23 . 5 . 1667–77 . Mar 2003 . 12629171 . 6741975 . 10.1523/JNEUROSCI.23-05-01667.2003.
6. Huda Zoghbi . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
7. Pulido R, Serra-Pagès C, Tang M, Streuli M . The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1 . Proc. Natl. Acad. Sci. U.S.A. . 92 . 25 . 11686–90 . Dec 1995 . 8524829 . 40467 . 10.1073/pnas.92.25.11686. 1995PNAS...9211686P . free .