Lipophosphoglycan Explained

Lipophosphoglycan (LPG) is a class of molecules found on the surface of some eukaryotes, in particular protozoa. Each is made up of two parts, lipid and polysaccharide (also called glycan). They are bonded by a phosphodiester, hence the name lipo-phospho-glycan.[1]

One species with extensive lipophosphoglycan coating is Leishmania, a group of single-celled protozoan parasite which cause leishmaniasis in many mammals, including humans. Their coats help modulate their hosts' immunological responses.[2]

Notes and References

  1. Leishmania lipophosphoglycan: how to establish structure-activity relationships for this highly complex and multifunctional glycoconjugate?. Claire-Lise . Forestier . Qi . Gao. Geert-Jan . Boons. Frontiers in Cellular and Infection Microbiology. 25653924. 4. 193 . 10.3389/fcimb.2014.00193 . 4301024 . 2014. 193 . free .
  2. The lipophosphoglycan of Leishmania parasites.. SJ. Turco . A. Descoteaux. Annual Review of Microbiology. 1444269. 46. 10.1146/annurev.mi.46.100192.000433. 1992. 65–94.

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