Linolenate 9R-lipoxygenase explained

Linolenate 9R-lipoxygenase
Ec Number:	1.13.11.61

Linolenate 9R-lipoxygenase (NspLOX, (9R)-LOX, linoleate 9R-dioxygenase) is an enzyme with systematic name alpha-linolenate:oxygen (9R)-oxidoreductase.^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

alpha-linolenate + O₂

\rightleftharpoons (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate

In cyanobacteria the enzyme is involved in oxylipin biosynthesis.

Notes and References

1. Jernerén F, Hoffmann I, Oliw EH . Linoleate 9R-dioxygenase and allene oxide synthase activities of Aspergillus terreus . Archives of Biochemistry and Biophysics . 495 . 1 . 67–73 . March 2010 . 20043865 . 10.1016/j.abb.2009.12.022 .
2. Andreou AZ, Vanko M, Bezakova L, Feussner I . Properties of a mini 9R-lipoxygenase from Nostoc sp. PCC 7120 and its mutant forms . Phytochemistry . 69 . 9 . 1832–7 . June 2008 . 18439634 . 10.1016/j.phytochem.2008.03.002 .
3. Lang I, Göbel C, Porzel A, Heilmann I, Feussner I . A lipoxygenase with linoleate diol synthase activity from Nostoc sp. PCC 7120 . The Biochemical Journal . 410 . 2 . 347–57 . March 2008 . 18031288 . 10.1042/BJ20071277 .