Linoleate 9S-lipoxygenase explained

Linoleate 9S-lipoxygenase
Ec Number:	1.13.11.58

Linoleate 9S-lipoxygenase (9-lipoxygenase, 9S-lipoxygenase, linoleate 9-lipoxygenase, LOX1 (gene), 9S-LOX) is an enzyme with systematic name linoleate:oxygen 9S-oxidoreductase.^{[1] [2] [3] [4]} This enzyme catalyses the following chemical reaction

linoleate + O₂

\rightleftharpoons (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate

Linoleate 9S-lipoxygenase contains nonheme iron.

Notes and References

1. Vellosillo T, Martínez M, López MA, Vicente J, Cascón T, Dolan L, Hamberg M, Castresana C . Oxylipins produced by the 9-lipoxygenase pathway in Arabidopsis regulate lateral root development and defense responses through a specific signaling cascade . The Plant Cell . 19 . 3 . 831–46 . March 2007 . 17369372 . 1867370 . 10.1105/tpc.106.046052 .
2. Boeglin WE, Itoh A, Zheng Y, Coffa G, Howe GA, Brash AR . Investigation of substrate binding and product stereochemistry issues in two linoleate 9-lipoxygenases . Lipids . 43 . 11 . 979–87 . November 2008 . 18795358 . 4710486 . 10.1007/s11745-008-3230-1 .
3. Andreou AZ, Hornung E, Kunze S, Rosahl S, Feussner I . On the substrate binding of linoleate 9-lipoxygenases . Lipids . 44 . 3 . 207–15 . March 2009 . 19037675 . 10.1007/s11745-008-3264-4 . 4004916 .
4. Bannenberg G, Martínez M, Hamberg M, Castresana C . Diversity of the enzymatic activity in the lipoxygenase gene family of Arabidopsis thaliana . Lipids . 44 . 2 . 85–95 . February 2009 . 18949503 . 10.1007/s11745-008-3245-7 . 19170797 .