Linoleate 10R-lipoxygenase explained

Linoleate 10R-lipoxygenase
Ec Number:1.13.11.62

Linoleate 10R-lipoxygenase (10R-DOX, (10R)-dioxygenase, 10R-dioxygenase) is an enzyme with systematic name linoleate:oxygen (10R)-oxidoreductase.[1] [2] This enzyme catalyses the following chemical reaction

linoleate + O2

\rightleftharpoons

(8E,10R,12Z)-10-hydroperoxy-8,12-octadecadienoate

Linoleate 10R-lipoxygenase is involved in biosynthesis of oxylipins.

Notes and References

  1. Garscha U, Oliw EH . Leucine/valine residues direct oxygenation of linoleic acid by (10R)- and (8R)-dioxygenases: expression and site-directed mutagenesis oF (10R)-dioxygenase with epoxyalcohol synthase activity . The Journal of Biological Chemistry . 284 . 20 . 13755–65 . May 2009 . 19289462 . 2679477 . 10.1074/jbc.M808665200 . free .
  2. Jernerén F, Garscha U, Hoffmann I, Hamberg M, Oliw EH . Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus . Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids . 1801 . 4 . 503–7 . April 2010 . 20045744 . 10.1016/j.bbalip.2009.12.012 .

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