| Differential: | increased calcium concentration in the blood |
The limbus sign is a ring of dystrophic calcification evident as a "milky precipitate" (i.e. abnormal white color) at the corneal limbus. The corneal limbus is the part of the eye where the cornea (front/center) meets the sclera (white part of the eye). Thought to be caused by increased calcium concentration in the blood, this sign however persists after calcium phosphate concentration returns to normal.[1] Compare the limbus sign (calcification) with arcus senilis (lipid).[2]