Lilopristone Explained

Lilopristone (INN) (developmental code names ZK-98734, ZK-734) is a synthetic, steroidal antiprogestogen with additional antiglucocorticoid activity which was developed by Schering and was patented in 1985.^{[1] [2] [3] [4]} It is described as an abortifacient and endometrial contraceptive.^[5] The drug differs from mifepristone only in the structure of its C17α side chain, and is said to have much reduced antiglucocorticoid activity in comparison.^[6]

See also

• Aglepristone
• Onapristone
• Telapristone
• Toripristone

Further reading

• Puri CP, Katkam RR, D'Souza A, Elger WA, Patil RK . Effects of progesterone antagonist, lilopristone (ZK 98.734), on induction of menstruation, inhibition of nidation, and termination of pregnancy in bonnet monkeys . Biology of Reproduction . 43 . 3 . 437–43 . September 1990 . 2271724 . 10.1095/biolreprod43.3.437 . free .
• Puri CP, Patil RK, Kholkute SD, Elger WA, Swamy XR . Progesterone antagonist lilopristone: a potent abortifacient in the common marmoset . American Journal of Obstetrics and Gynecology . 161 . 1 . 248–53 . July 1989 . 2502015 . 10.1016/0002-9378(89)90274-3 .

Notes and References

1. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 733–.
2. Book: Rao KA . Textbook of Gynaecology. November 2009. Elsevier India. 978-81-312-1526-5. 187–.
3. Book: Baird DT, Schütz G, Krattenmacher R . Organ-Selective Actions of Steroid Hormones. 9 March 2013. Springer Science & Business Media. 978-3-662-09153-1. 108–.
4. Book: Milne GW . Drugs: Synonyms and Properties: Synonyms and Properties. 8 May 2018. Taylor & Francis. 978-1-351-78989-9. 23–.
5. Book: Deshpande H . Practical Management of Ovulation Induction. 12 February 2016. JP Medical Ltd. 978-93-5250-028-4. 29–.
6. Book: Van Look PF, Pérez-Palacios G, ((World Health Organization)). Contraceptive research and development, 1984 to 1994: the road from Mexico City to Cairo and beyond. 1994. Oxford University Press. 978-0-19-563630-7. 169. [...] lilopristone, which differs from mifepristone only in the structure of the 17a side chain, is said to have a much reduced antiglucocorticoid activity (Neef et al., 1984)..