Levophacetoperane Explained

Levophacetoperane (Lidépran, Phacétoperane) is a psychostimulant developed by Rhône-Poulenc in the 1950s.[1] The drug has been used as an antidepressant and anorectic.[2] [3] It is the reverse ester of methylphenidate. Phacetoperane and levophacetoperane have been used as wakefulness-promoting agents in the treatment of narcolepsy.[4]

See also

Notes and References

  1. New esters . US . 2928835 . Rhône-Poulenc . 15 March 1960 . Marie JN, Michel JR .
  2. Delbeke FT, Debackere M . Isolation and detection of methylphenidate, phacetoperane and some other sympatomimetic central nervous stimulants with special reference to doping. I. Gas chromatographic detection procedure with electron capture detection for some secondary amines . Journal of Chromatography . 106 . 2 . 412–7 . March 1975 . 239015 . 10.1016/S0021-9673(00)93853-6 .
  3. Phacetoperane for the treatment of attention-deficit hyperactivity disorder . US . 20150038533 . Assistance Publique – Hôpitaux de Paris . 5 February 2015 . Konofal E, Figadere B.
  4. Konofal E . From past to future: 50 years of pharmacological interventions to treat narcolepsy . Pharmacol Biochem Behav . 241 . 173804 . August 2024 . 38852786 . 10.1016/j.pbb.2024.173804 . free .

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