Leukotriene C4 hydrolase explained

Leukotriene-C4 hydrolase
Ec Number:	3.4.19.14

Leukotriene-C4 hydrolase (gamma-glutamyl leukotrienase) is an enzyme.^{[1] [2] [3] [4]} Gamma-glutamyltransferase 5 (GGT5) is a human gene which encodes an enzyme protein that belongs to this class of enzymes. This enzyme catalyses the following chemical reaction

leukotriene C4 + H₂O

\rightleftharpoons leukotriene D4 + L-glutamate

The mouse enzyme is specific for leukotriene C4.

Notes and References

1. Carter BZ, Wiseman AL, Orkiszewski R, Ballard KD, Ou CN, Lieberman MW . Metabolism of leukotriene C4 in gamma-glutamyl transpeptidase-deficient mice . The Journal of Biological Chemistry . 272 . 19 . 12305–10 . May 1997 . 9139674 . 10.1074/jbc.272.19.12305 . free.
2. Shi ZZ, Han B, Habib GM, Matzuk MM, Lieberman MW . Disruption of gamma-glutamyl leukotrienase results in disruption of leukotriene D(4) synthesis in vivo and attenuation of the acute inflammatory response . Molecular and Cellular Biology . 21 . 16 . 5389–95 . August 2001 . 11463821 . 87261 . 10.1128/mcb.21.16.5389-5395.2001 .
3. Han B, Luo G, Shi ZZ, Barrios R, Atwood D, Liu W, Habib GM, Sifers RN, Corry DB, Lieberman MW . Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo . The American Journal of Pathology . 161 . 2 . 481–90 . August 2002 . 12163373 . 1850737 . 10.1016/s0002-9440(10)64204-6 .
4. Wickham S, West MB, Cook PF, Hanigan MH . Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes . Analytical Biochemistry . 414 . 2 . 208–14 . July 2011 . 21447318 . 3099546 . 10.1016/j.ab.2011.03.026 .