Leteprinim Explained

Leteprinim (Neotrofin, AIT-082) is a hypoxanthine derivative drug with neuroprotective and nootropic effects.[1] [2] [3] It stimulates release of nerve growth factors and enhances survival of neurons in the brain,[4] [5] [6] [7] [8] and is under development as a potential treatment for neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and stroke.[9] [10]

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Notes and References

  1. Di Iorio P, Virgilio A, Giuliani P, Ballerini P, Vianale G, Middlemiss PJ, Rathbone MP, Ciccarelli R . 43094767 . AIT-082 is neuroprotective against kainate-induced neuronal injury in rats . Experimental Neurology . 169 . 2 . 392–9 . June 2001 . 11358452 . 10.1006/exnr.2001.7654 .
  2. Lahiri DK, Ge YW, Farlow MR . Effect of a memory-enhancing drug, AIT-082, on the level of synaptophysin . Annals of the New York Academy of Sciences . 903 . 1 . 387–93 . April 2000 . 10818529 . 10.1111/j.1749-6632.2000.tb06390.x . 2000NYASA.903..387L . 33710679 .
  3. Yan R, Nguyen Q, Gonzaga J, Johnson M, Ritzmann RF, Taylor EM . 25028981 . Reversal of cycloheximide-induced memory disruption by AIT-082 (Neotrofin) is modulated by, but not dependent on, adrenal hormones . Psychopharmacology . 166 . 4 . 400–7 . April 2003 . 12605287 . 10.1007/s00213-002-1350-5 .
  4. Rathbone MP, Middlemiss PJ, Crocker CE, Glasky MS, Juurlink BH, Ramirez JJ, Ciccarelli R, Di Iorio P, Caciagli F . AIT-082 as a potential neuroprotective and regenerative agent in stroke and central nervous system injury . Expert Opinion on Investigational Drugs . 8 . 8 . 1255–62 . August 1999 . 15992149 . 10.1517/13543784.8.8.1255 .
  5. Ramirez JJ, Parakh T, George MN, Freeman L, Thomas AA, White CC, Becton A . The effects of Neotrofin on septodentate sprouting after unilateral entorhinal cortex lesions in rats . Restorative Neurology and Neuroscience . 20 . 1–2 . 51–9 . 2002 . 12237496 .
  6. Holmes M, Maysinger D, Foerster A, Pertens E, Barlas C, Diamond J . Neotrofin, a novel purine that induces NGF-dependent nociceptive nerve sprouting but not hyperalgesia in adult rat skin . Molecular and Cellular Neurosciences . 24 . 3 . 568–80 . November 2003 . 14664808 . 10.1016/s1044-7431(03)00217-3 . 13359687 .
  7. Jiang S, Khan MI, Middlemiss PJ, Lu Y, Werstiuk ES, Crocker CE, Ciccarelli R, Caciagli F, Rathbone MP . AIT-082 and methylprednisolone singly, but not in combination, enhance functional and histological improvement after acute spinal cord injury in rats . International Journal of Immunopathology and Pharmacology . 17 . 3 . 353–66 . 2004 . 15461869 . 10.1177/039463200401700315 . 26045848 .
  8. Calcutt NA, Freshwater JD, Hauptmann N, Taylor EM, Mizisin AP . Protection of sensory function in diabetic rats by Neotrofin . European Journal of Pharmacology . 534 . 1–3 . 187–93 . March 2006 . 16507305 . 10.1016/j.ejphar.2006.01.047 .
  9. Potkin SG, Alva G, Keator D, Carreon D, Fleming K, Fallon JH . Brain metabolic effects of Neotrofin in patients with Alzheimer's disease . Brain Research . 951 . 1 . 87–95 . September 2002 . 12231461 . 10.1016/s0006-8993(02)03140-2 . 23021393 .
  10. Johnston TH, Brotchie JM . Drugs in development for Parkinson's disease . Current Opinion in Investigational Drugs . 5 . 7 . 720–6 . July 2004 . 15298067 .

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