Laser lithotripsy explained

Laser lithotripsy

Laser lithotripsy is a surgical procedure to remove stones from urinary tract, i.e., kidney, ureter, bladder, or urethra.[1]

History

Laser lithotripsy was invented at the Wellman Center for Photo medicine at Massachusetts General Hospital in the 1980s to remove impacted urinary stones. Optical fibers carry light pulses that pulverize the stone. Candela licensed the technology and released the first commercial laser lithotripsy system.[2] Initially 504 nm dye lasers were used, then holmium lasers were studied in the 1990s.

Procedure

A urologist inserts a scope into the urinary tract to locate the stone. The scope may be a cystoscope, ureteroscope, renoscope or nephroscope. An optical fiber is inserted through the working channel of the scope, and laser light is directly emitted to the stone. The stone is fragmented and the remaining pieces are collected in a "basket" and/or washed out of the urinary tract, along with the finer particulate "dust."

The procedure is done under either local or general anesthesia and is considered a minimally-invasive procedure. It is widely available in most hospitals in the world.

Comparison

Laser lithotripsy (LL) has been evaluated against Extracorporeal Shock Wave lithotripsy (ESWL), finding both to be safe and effective.[3] [4] ESWL may be safer for small stones (<10 mm), but less effective for 10–20 mm stones. A 2013 meta-analysis found LL can treat larger stones (> 2 cm) with good stone-free and complication rates.[5]

Holmium laser lithotripsy had superior initial success and re-treatment rate compared to extracorporeal shock wave lithotripsy (ESWL) in a 2013 trial.[6]

The experimental thulium fiber laser (TFL) is being studied as a potential alternative to the holmium:YAG (Ho:YAG) laser for the treatment of kidney stones. The TFL has several potential advantages compared to Ho:YAG laser for lithotripsy, including a four times lower ablation threshold, a near single-mode beam profile, and higher pulse rates, resulting in up to four times as fast ablation rates and faster procedural times.

Lasers

Pulsed dye lasers have been used with fiber diameters of 200–550 microns[7] for lithotripsy of biliary and urinary stones.[8]

Ho:YAG lasers have wavelength of 2100 nm (infrared) and are used for medical procedures in urology and other areas. They have qualities of CO2 and Nd:Yag lasers, with ablative and coagulation effects.[9] Holmium laser use results in smaller fragments than 320 or 365 micron pulsed dye lasers or electrohydraulic and mechanical methods.[10]

Thulium fiber lasers are being investigated.[11] [12] [13] [14] [15]

See also

Notes and References

  1. Web site: Laser Lithotripsy | Winchester Hospital .
  2. Web site: Research Discoveries. Wellman Center for Photomedicine. 30 April 2011. dead. https://archive.today/20130415112815/http://www2.massgeneral.org/wellman/research-researchdiscoveries.htm. 15 April 2013.
  3. A Prospective Randomized Comparison Between Shock Wave Lithotripsy and Flexible Ureterorenoscopy for Lower Caliceal Stones ≤2 cm: A Single-Center Experience.. Nov 18, 2014. J. Endourol.. 10.1089/end.2013.0473. 25203489. 29. 575–579. Kumar A, Vasudeva P, Nanda B, Kumar N, Das MK, Jha SK. 5.
  4. Flexible Ureterorenoscopy versus Extracorporeal Shock Wave Lithotripsy for the treatment of upper/middle calyx kidney stones of 10-20 mm: a retrospective analysis of 174 patients.. Sep 24, 2014. SpringerPlus. 10.1186/2193-1801-3-557. 25332859. 3. 557. 4190185. Cecen K, Karadag MA, Demir A, Bagcioglu M, Kocaaslan R, Sofikerim M. 1 . free .
  5. Flexible ureteroscopy and laser lithotripsy for stones >2 cm: a systematic review and meta-analysis.. Oct 2012. J. Endourol.. 10.1089/end.2012.0217. 22642568. 26. 1257–63. Aboumarzouk OM, Monga M, Kata SG, Traxer O, Somani BK. 10.
  6. Management of impacted proximal ureteral stone: Extracorporeal shock wave lithotripsy versus ureteroscopy with holmium: YAG laser lithotripsy.. Apr 2013. Urol. Ann.. 10.4103/0974-7796.110004. 23798864. 5. 88–92. 3685752. Khalil M. 2 . free .
  7. Endoscopic pulsed-dye laser lithotripsy: 159 consecutive cases.. Feb 1994. J. Endourol.. 10.1089/end.1994.8.25. 8186779. 8. 25–7. Grasso M, Bagley DH. 1.
  8. Pulsed dye laser lithotripsy--currently applied to urologic and biliary calculi. October 1991. J. Clin. Laser Med. Surg.. 10.1089/clm.1991.9.355. 10150133. 9. 355–9. Grasso M, Bagley D, Sullivan K. 5.
  9. Laser prostatectomy with the holmium: YAG laser. Winter 1995. Tech. Urol.. 9118394. 1. 217–21. Chun SS, Razvi HA, Denstedt JD. 4.
  10. Holmium:YAG lithotripsy yields smaller fragments than lithoclast, pulsed dye laser or electrohydraulic lithotripsy. January 1998. J. Urol.. 10.1016/s0022-5347(01)63998-3. 9400428. 159. 17–23. Teichman Joel M.H.. 1.
  11. Wilson CR, Hardy LA, Irby PB, Fried NM. Collateral damage to the ureter and Nitinol stone baskets during thulium fiber laser lithotripsy. Lasers Surg. Med.. 47. 5. 403–10. July 2015. 25872759. 10.1002/lsm.22348 . 35302695 .
  12. Wilson CR, Hutchens TC, Hardy LA, Irby PB, Fried NM. A Miniaturized, 1.9F Integrated Optical Fiber and Stone Basket for Use in Thulium Fiber Laser Lithotripsy. J. Endourol.. 29. 10. 1110–4. October 2015. 26167738. 10.1089/end.2015.0124 .
  13. Book: Hardy. L.A. Wilson. C.R.. Irby. P.B.. Fried. N.M.. Bernard . Nikiforos . Haishan . Hyun Wook . Brian J. F. . Justus F. . Guillermo J. . Kenton W. . Laura . Andreas . Michael D. . Choi . Kollias . Zeng . Kang . Wong . Ilgner . Tearney . Gregory . Marcu . Mandelis . Morris . Rapid vaporization of kidney stones, ex vivo, using a Thulium fiber laser at pulse rates up to 500 Hz with a stone basket . Photonic Therapeutics and Diagnostics X. Proceedings of the SPIE. 8926. 89261H. 2014. 10.1117/12.2037263. 10.1.1.819.6910. 121794649 .
  14. Hardy L.A, Wilson C.R., Irby P.B., Fried N.M.. 2014. Thulium fiber laser lithotripsy in an in vitro ureter model. J. Biomed. Opt.. 19. 12. 128001. 10.1117/1.jbo.19.12.128001. 25518001. 2014JBO....19l8001H . 12424266 . free.
  15. Blackmon R.L., Hutchens T.C., Hardy L.A., Wilson C.R., Irby P.B., Fried N.M.. 2015. Thulium fiber laser ablation of kidney stones using a 50-μm-core silica optical fiber. Opt. Eng.. 54. 1. 011004. 10.1117/1.oe.54.1.011004. 2015OptEn..54a1004B . 120650738 .

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