Lanatoside C Explained

Lanatoside C (or isolanid) is a cardiac glycoside, a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat). Lanatoside C can be used orally^[1] or by the intravenous route.^[2] It is marketed in a number of countries and is also available in generic form.^[3] Its main indications are rapid response atrial fibrilation and paroxysmal supraventricular tachycardia, two common types of arrhythmia.

It is found in Digitalis lanata.^[4]

Chemistry

The substance is composed of four monosaccharides (glucose, 3-acetyldigitoxose and two digitoxoses) and an aglycon named digoxigenin.^[5]

Notes and References

1. Lypka A, Lazowski J . [Comparative study of blood serum concentrations of digoxin and lanatoside C after single oral administration] . Polish . Wiadomosci Lekarskie . 32 . 18 . 1277–81 . September 1979 . 506267 . Comparative study of blood serum concentrations of digoxin and lanatoside C after single oral administration .
2. Tàmmaro AE, Baldoli C . [On some immediate effects of the intravenous administration of desacetyl-lanatoside C in aged subjects] . Italian . La Clinica Terapeutica . 40 . 2 . 157–61 . January 1967 . 5600177 . On some immediate effects of the intravenous administration of desacetyl-lanatoside C in aged subjects .
3. Web site: Drugs.com . Lanatoside C . International Drug Names .
4. Ikeda Y, Fujii Y, Yamazaki M . Determination of Lanatoside C and Digoxin in Digitalis lanata by HPLC and its Application to Analysis of the Fermented Leaf Powder. . Journal of Natural Products . June 1992 . 55 . 6 . 748–52 . 10.1021/np50084a007 .
5. Web site: Cardiac Glycosides . Desai UR . 2005 . .