Lactotriaosylceramide beta-1,4-galactosyltransferase explained

Lactotriaosylceramide beta-1,4-galactosyltransferase
Ec Number:	2.4.1.275

Lactotriaosylceramide beta-1,4-galactosyltransferase (beta4Gal-T4, UDP-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide beta-1,4-galactosyltransferase) is an enzyme with systematic name UDP-alpha-D-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 4-beta-D-galactosyltransferase.^[1] This enzyme catalyses the following chemical reaction

UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

\rightleftharpoons UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-galactosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

Notes and References

1. Schwientek T, Almeida R, Levery SB, Holmes EH, Bennett E, Clausen H . Cloning of a novel member of the UDP-galactose:beta-N-acetylglucosamine beta1,4-galactosyltransferase family, beta4Gal-T4, involved in glycosphingolipid biosynthesis . The Journal of Biological Chemistry . 273 . 45 . 29331–40 . November 1998 . 9792633 . 10.1074/jbc.273.45.29331 . free .