Lactaldehyde dehydrogenase explained

lactaldehyde dehydrogenase
Ec Number:1.2.1.22
Cas Number:37250-90-1
Go Code:0008911

In enzymology, a lactaldehyde dehydrogenase is an enzyme that catalyzes the chemical reaction

(S)-lactaldehyde + NAD+ + H2O

\rightleftharpoons

(S)-lactate + NADH + 2 H+

The 3 substrates of this enzyme are (S)-lactaldehyde, NAD+, and H2O, whereas its 3 products are (S)-lactate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-lactaldehyde:NAD+ oxidoreductase. Other names in common use include L-lactaldehyde:NAD+ oxidoreductase, and nicotinamide adenine dinucleotide (NAD+)-linked dehydrogenase. This enzyme participates in pyruvate metabolism.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes,,, and .

References