Labdane Explained

Labdane is a natural bicyclic diterpene. It forms the structural core for a wide variety of natural products collectively known as labdanes or labdane diterpenes. The labdanes were so named because the first members of the class were originally obtained from labdanum, a resin derived from the gum rockrose.^{[1] [2]}

A variety of biological activities have been determined for labdane diterpenes including antibacterial, antifungal, antiprotozoal, and anti-inflammatory activities.^[3]

Example labdane derivatives

• Forskolin
• Galanolactone^[4]
• Isocupressic acid - is an abortifacient component of Cupressus macrocarpa.^[5]
• Medigenin
• Sclareol
• Stemodene

See also

• Abietane

Notes and References

1. Cocker, J. D. . Halsall, T. G. . Bowers, A. . The chemistry of gum labdanum. I. Some acidic constituents. Journal of the Chemical Society. 1956. 4259–62. 10.1039/jr9560004259 .
2. Cocker, J. D. . Halsall, T. G. . The chemistry of gum labdanum. II. The structure of labdanolic acid. Journal of the Chemical Society. 1956. 4262–71. 10.1039/jr9560004262 .
3. Book: Studies in Natural Product Chemistry : Bioactive Natural Products, Part F . Atta-Ur-Rahman . 978-0-08-044001-9. 1988 .
4. Kenmogne . Marguerite . Prost . Elise . Harakat . Dominique . Jacquier . Marie-José . Frédérich . Michel . Sondengam . Lucas B. . Zèches . Monique . Waffo-Téguo . Pierre . Five labdane diterpenoids from the seeds of Aframomum zambesiacum . Phytochemistry . 1 March 2006 . 67 . 5 . 433–438 . 10.1016/j.phytochem.2005.10.015 . 16321410 .
5. 10.1080/00480169.1996.35946. 16031906. Isocupressic acid, an abortifacient component of Cupressus macrocarpa. New Zealand Veterinary Journal. 44. 3. 109. 1996. Parton. K. Gardner. D. Williamson. N.B.