L-aminoadipate-semialdehyde dehydrogenase explained

L-aminoadipate-semialdehyde dehydrogenase
Ec Number:	1.2.1.31
Cas Number:	9067-87-2
Go Code:	0004043
Width:	270

In enzymology, a L-aminoadipate-semialdehyde dehydrogenase is an enzyme that catalyzes the chemical reaction

L-2-aminoadipate 6-semialdehyde + NAD(P)+ + H₂O

\rightleftharpoons L-2-aminoadipate + NAD(P)H + H⁺

The 4 substrates of this enzyme are L-2-aminoadipate 6-semialdehyde, NAD⁺, NADP⁺, and H₂O, whereas its 4 products are L-2-aminoadipate, NADH, NADPH, and H⁺.

This enzyme participates in lysine biosynthesis and biodegradation.

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase. Other names in common use include:

• aminoadipate semialdehyde dehydrogenase,
• 2-aminoadipate semialdehyde dehydrogenase,
• alpha-aminoadipate-semialdehyde dehydrogenase,
• alpha-aminoadipate reductase,
• 2-aminoadipic semialdehyde dehydrogenase,
• L-alpha-aminoadipate delta-semialdehyde oxidoreductase,
• L-alpha-aminoadipate delta-semialdehyde:NAD+ oxidoreductase,
• L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine,
• and dinucleotide oxidoreductase.

References

• Calvert AF, Rodwell VW . 1966 . Metabolism of pipecolic acid in a Pseudomonas species. 3 L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase . J. Biol. Chem. . 241 . 409 - 14 . 4285660 . 2 .