Lysophosphatidylinositol Explained

Lysophosphatidylinositol (LPI, lysoPI), or L-α-lysophosphatidylinositol, is an endogenous lysophospholipid and endocannabinoid neurotransmitter.[1] LPI, along with its 2-arachidonoyl- derivative, 2-arachidonoyl lysophosphatidylinositol (2-ALPI), have been proposed as the endogenous ligands of GPR55.[2] [3] [4] [5]

See also

Notes and References

  1. Li X, Wang L, Fang P, etal . Lysophospholipids induce innate immune transdifferentiation of endothelial cells, resulting in prolonged endothelial activation. . The Journal of Biological Chemistry . May 2018 . 293 . 28 . 11033–11045 . 29769317 . 10.1074/jbc.RA118.002752. 6052225 . free .
  2. Oka S, Nakajima K, Yamashita A, Kishimoto S, Sugiura T . Identification of GPR55 as a lysophosphatidylinositol receptor . Biochemical and Biophysical Research Communications . 362 . 4 . 928–34 . November 2007 . 17765871 . 10.1016/j.bbrc.2007.08.078 .
  3. Henstridge CM, Balenga NA, Ford LA, Ross RA, Waldhoer M, Irving AJ . The GPR55 ligand L-alpha-lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation . The FASEB Journal . 23 . 1 . 183–93 . January 2009 . 18757503 . 10.1096/fj.08-108670 . free . 27142069 .
  4. 10.1016/j.bbalip.2012.01.009 . Lysophosphatidylinositol signalling: New wine from an old bottle . 2012 . Piñeiro . Roberto . Falasca . Marco . Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids . 1821 . 4 . 694–705 . 22285325.
  5. Oka S, Toshida T, Maruyama K, Nakajima K, Yamashita A, Sugiura T . 2-Arachidonoyl-sn-glycero-3-phosphoinositol: a possible natural ligand for GPR55 . Journal of Biochemistry . 145 . 1 . 13–20 . January 2009 . 18845565 . 10.1093/jb/mvn136 .

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