Kynapcin Explained

right|thumb|Skeletal formula of kynapcin-24Kynapcin is a general name for a number of dibenzofuranyl derivatives of the molecule polyozellin, present in the fungus Polyozellus multiplex. Like polyozellin, some kynapcins inhibit prolyl endopeptidase, an enzyme that has a role in processing proteins including amyloid precursor protein. Chemicals that inhibit prolyl endopeptidase have attracted research interest due to their potential therapeutic effects.^[1] Several kynapcins have been found in P. multiplex, each with different chemical properties, including kynapcin-12,^[2] kynapcin-13 and -28,^[3] and -24.^[4] A total synthesis of kynapcin-24 was achieved in 2009.^[5]

Notes and References

1. Hwang JS, Song KS, Kim WG, Lee TH, Koshino H, Yoo ID . Polyozellin, a new inhibitor of prolyl endopeptidase from Polyozellus multiplex . The Journal of Antibiotics . 50 . 9 . 773–777. 1997. 9360624 . 10.7164/antibiotics.50.773. free .
2. Lee HJ, Rhee IK, Lee KB, Yoo ID, Song KS . Kynapcin-12, a new p-terphenyl derivative from Polyozellus multiplex, inhibits prolyl endopeptidase . The Journal of Antibiotics . 53 . 7 . 714–719 . 2000 . 10994814 . 10.7164/antibiotics.53.714. free .
3. Kim SI, Park IH, Song KS . kynapcin-13 and -28, new benzofuran prolyl endopeptidase inhibitors from Polyozellus multiplex . The Journal of Antibiotics . 55 . 7 . 623–628 . 2002 . 12243451 . 10.7164/antibiotics.55.623. free .
4. Song KS, Raskin I . 2002 . A prolyl endopeptidase-inhibiting benzofuran dimer from Polyozellus multiflex . Journal of Natural Products . 65 . 1 . 76–78 . 10.1021/np010194b . 11809072.
5. Yang LY, Chang CF, Huang YC, Lee YJ, Hu CC, Tseng TH . 2009 . The first total synthesis of kynapcin-24 by palladium catalysis . Synthesis . 2009 . 7. 1175–1179 . 10.1055/s-0028-1087998 .