Keratin 17 Explained

Keratin, type I cytoskeletal 17 is a protein that in humans is encoded by the KRT17 gene.^{[1] [2] [3] [4]}

Keratin 17 is a type I cytokeratin. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in the gene encoding this protein lead to PC-K17 (previously known as Jackson-Lawler) type pachyonychia congenita and steatocystoma multiplex.

Interactions

Keratin 17 has been shown to interact with CCDC85B.^[5]

Further reading

• Flohr T, Buwitt U, Bonnekoh B, Decker T, Böttger EC . Interferon-gamma regulates expression of a novel keratin class I gene . Eur. J. Immunol. . 22 . 4 . 975–9 . 1992 . 1372562 . 10.1002/eji.1830220415 . 85892865 .
• Trask DK, Band V, Zajchowski DA, Yaswen P, Suh T, Sager R . Keratins as markers that distinguish normal and tumor-derived mammary epithelial cells . Proc. Natl. Acad. Sci. U.S.A. . 87 . 6 . 2319–23 . 1990 . 1690428 . 53678 . 10.1073/pnas.87.6.2319 . 1990PNAS...87.2319T . free .
• Kartasova T, Cornelissen BJ, Belt P, van de Putte P . Effects of UV, 4-NQO and TPA on gene expression in cultured human epidermal keratinocytes . Nucleic Acids Res. . 15 . 15 . 5945–62 . 1987 . 2442723 . 306060 . 10.1093/nar/15.15.5945 .
• Takahashi K, Folmer J, Coulombe PA . Increased expression of keratin 16 causes anomalies in cytoarchitecture and keratinization in transgenic mouse skin . J. Cell Biol. . 127 . 2 . 505–20 . 1994 . 7523421 . 2120213 . 10.1083/jcb.127.2.505 .
• Munro CS, Carter S, Bryce S, Hall M, Rees JL, Kunkeler L, Stephenson A, Strachan T . A gene for pachyonychia congenita is closely linked to the keratin gene cluster on 17q12-q21 . J. Med. Genet. . 31 . 9 . 675–8 . 1995 . 7529318 . 1050075 . 10.1136/jmg.31.9.675 .
• Leigh IM, Navsaria H, Purkis PE, McKay IA, Bowden PE, Riddle PN . Keratins (K16 and K17) as markers of keratinocyte hyperproliferation in psoriasis in vivo and in vitro . Br. J. Dermatol. . 133 . 4 . 501–11 . 1995 . 7577575 . 10.1111/j.1365-2133.1995.tb02696.x . 85097321 .
• Smith FJ, Corden LD, Rugg EL, Ratnavel R, Leigh IM, Moss C, Tidman MJ, Hohl D, Huber M, Kunkeler L, Munro CS, Lane EB, McLean WH . Missense mutations in keratin 17 cause either pachyonychia congenita type 2 or a phenotype resembling steatocystoma multiplex . J. Invest. Dermatol. . 108 . 2 . 220–3 . 1997 . 9008238 . 10.1111/1523-1747.ep12335315 . free .
• Covello SP, Smith FJ, Sillevis Smitt JH, Paller AS, Munro CS, Jonkman MF, Uitto J, McLean WH . Keratin 17 mutations cause either steatocystoma multiplex or pachyonychia congenita type 2 . Br. J. Dermatol. . 139 . 3 . 475–80 . 1999 . 9767294 . 10.1046/j.1365-2133.1998.02413.x . 22421872 .
• McGowan KM, Coulombe PA . Onset of keratin 17 expression coincides with the definition of major epithelial lineages during skin development . J. Cell Biol. . 143 . 2 . 469–86 . 1998 . 9786956 . 2132846 . 10.1083/jcb.143.2.469 .
• Schön M, Benwood J, O'Connell-Willstaedt T, Rheinwald JG . Human sweat gland myoepithelial cells express a unique set of cytokeratins and reveal the potential for alternative epithelial and mesenchymal differentiation states in culture . J. Cell Sci. . 112 . 12 . 1925–36 . 1999 . 10.1242/jcs.112.12.1925 . 10341211 . free .
• Celebi JT, Tanzi EL, Yao YJ, Michael EJ, Peacocke M . Mutation report: identification of a germline mutation in keratin 17 in a family with pachyonychia congenita type 2 . J. Invest. Dermatol. . 113 . 5 . 848–50 . 1999 . 10571744 . 10.1046/j.1523-1747.1999.00762.x . free .
• Smith FJ, Coleman CM, Bayoumy NM, Tenconi R, Nelson J, David A, McLean WH . Novel keratin 17 mutations in pachyonychia congenita type 2 . J. Invest. Dermatol. . 116 . 5 . 806–8 . 2001 . 11348474 . 10.1046/j.0022-202x.2001.doc.x .
• Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y . Protein-protein interaction panel using mouse full-length cDNAs . Genome Res. . 11 . 10 . 1758–65 . 2001 . 11591653 . 311163 . 10.1101/gr.180101 .
• Hashiguchi T, Yotsumoto S, Shimada H, Terasaki K, Setoyama M, Kobayashi K, Saheki T, Kanzaki T . A novel point mutation in the keratin 17 gene in a Japanese case of pachyonychia congenita type 2 . J. Invest. Dermatol. . 118 . 3 . 545–7 . 2002 . 11874497 . 10.1046/j.0022-202x.2001.01701.x . free .
• Terrinoni A, Smith FJ, Didona B, Canzona F, Paradisi M, Huber M, Hohl D, David A, Verloes A, Leigh IM, Munro CS, Melino G, McLean WH . Novel and recurrent mutations in the genes encoding keratins K6a, K16 and K17 in 13 cases of pachyonychia congenita . J. Invest. Dermatol. . 117 . 6 . 1391–6 . 2002 . 11886499 . 10.1046/j.0022-202x.2001.01565.x . free .
• Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ . Functional proteomic analysis of human nucleolus . Mol. Biol. Cell . 13 . 11 . 4100–9 . 2003 . 12429849 . 133617 . 10.1091/mbc.E02-05-0271 .
• van de Rijn M, Perou CM, Tibshirani R, Haas P, Kallioniemi O, Kononen J, Torhorst J, Sauter G, Zuber M, Köchli OR, Mross F, Dieterich H, Seitz R, Ross D, Botstein D, Brown P . Expression of cytokeratins 17 and 5 identifies a group of breast carcinomas with poor clinical outcome . Am. J. Pathol. . 161 . 6 . 1991–6 . 2003 . 12466114 . 1850928 . 10.1016/S0002-9440(10)64476-8 .

External links

• GeneReviews/NCBI/NIH/UW entry on Pachyonychia Congenita

Notes and References

1. McLean WH, Rugg EL, Lunny DP, Morley SM, Lane EB, Swensson O, Dopping-Hepenstal PJ, Griffiths WA, Eady RA, Higgins C . Keratin 16 and keratin 17 mutations cause pachyonychia congenita . Nat Genet . 9 . 3 . 273–8 . Jul 1995 . 7539673 . 10.1038/ng0395-273 . 1873772 .
2. Troyanovsky SM, Leube RE, Franke WW . Characterization of the human gene encoding cytokeratin 17 and its expression pattern . Eur J Cell Biol . 59 . 1 . 127–37 . Jan 1993 . 1281771 .
3. Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW . New consensus nomenclature for mammalian keratins . J Cell Biol . 174 . 2 . 169–74 . Jul 2006 . 16831889 . 2064177 . 10.1083/jcb.200603161 .
4. Web site: Entrez Gene: KRT17 keratin 17.
5. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .