KatG explained

KatG is an enzyme that functions as both catalase and peroxidase. Its mutation is the cause for Mycobacterium (specifically M. tuberculosis) resistance with the drug isoniazid, which targets the mycolic acids within the tuberculosis bacteria.[1] Due to both its catalase and peroxidase activity, this enzyme protects M. Tuberculosis against reactive oxygen species. M. tuberculosis' survival within macrophages depends on the KatG enzyme.[2] [3]

Notes and References

  1. Johnsson. Kai. Overexpression, Purification, and Characterization of the Catalase-peroxidase KatG from Mycobacterium tuberculosis. Journal of Biological Chemistry. 1997. 272. 5. 2834–2840. 10.1074/jbc.272.5.2834. 9006925. 23882303. Elsevier. free.
  2. Heym. B. July 1993. Characterization of the katG gene encoding a catalase-peroxidase required for the isoniazid susceptibility of Mycobacterium tuberculosis. Journal of Bacteriology. 175. 13. 4255–4259. 10.1128/jb.175.13.4255-4259.1993. 8320241. 204858.
  3. Cockerill. FR. 1995. Rapid identification of a point mutation of the Mycobacterium tuberculosis catalase-peroxidase (katG) gene associated with isoniazid resistance. The Journal of Infectious Diseases. 171. 1. 240–245. 10.1093/infdis/171.1.240. 7798673. Pubmed.

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