Jararhagin Explained

Jararhagin
Ec Number:	3.4.24.73
Cas Number:	160477-79-2

Jararhagin (HF2-proteinase, JF1) is an enzyme.^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

Hydrolysis of -His¹⁰-Leu-, -Ala¹⁴-Leu-, -Tyr¹⁶-Leu-and -Phe²⁴-Phe- bonds in insulin B chain

This endopeptidase is present in the venom of the jararaca snake (Bothrops jararaca).

Notes and References

1. Book: Some physical and biochemical characteristics of HF2, one of the hemorrhagic factors in the venom of Bothrops jararaca . Animal, Plant and Microbial Toxins . Mandelbaum, F.R., Reichl, A.P. and Assakura, M.T. . 1976 . 111–121 . Ohsaka, A., Hayashi, K. and Sawai, Y. . Plenum Press . New York .
2. Assakura MT, Reichl AP, Mandelbaum FR . Comparison of immunological, biochemical and biophysical properties of three hemorrhagic factors isolated from the venom of Bothrops jararaca (jararaca) . Toxicon . 24 . 9 . 943–6 . 1986 . 3810664 . 10.1016/0041-0101(86)90094-2 .
3. Paine MJ, Desmond HP, Theakston RD, Crampton JM . Purification, cloning, and molecular characterization of a high molecular weight hemorrhagic metalloprotease, jararhagin, from Bothrops jararaca venom. Insights into the disintegrin gene family . The Journal of Biological Chemistry . 267 . 32 . 22869–76 . November 1992 . 10.1016/S0021-9258(18)50027-2 . 1385408 . free .