Isopropylphenidate Explained

Isopropylphenidate (also known as IPH and IPPD) is a piperidine based stimulant drug, closely related to methylphenidate, but with the methyl ester replaced by an isopropyl ester. It has similar effects to methylphenidate but with a longer duration of action,^{[1] [2]} and was banned in the UK as a Temporary Class Drug from April 2015 following its unapproved sale as a designer drug.^[3]

It has been researched as potential methylphenidate replacement for ADHD and narcolepsy, because of fewer side effects.^{[4] [2]}

See also

• 3,4-Dichloromethylphenidate
• Ethylphenidate
• Desoxypipradrol
• HDEP-28
• HDMP-28
• Propylphenidate

Notes and References

1. Markowitz JS, Zhu HJ, Patrick KS . Isopropylphenidate: an ester homolog of methylphenidate with sustained and selective dopaminergic activity and reduced drug interaction liability . Journal of Child and Adolescent Psychopharmacology . 23 . 10 . 648–54 . December 2013 . 24261661 . 10.1089/cap.2013.0074 . 2027.42/140321 . free .
2. Isopropylphenidate for Treatment of Attention-Deficit/Hyperactivity Disorder and Fatigue-Related Disorders and Conditions . US . 20120245201 . application . 2012-09-27 . Markowitz JS, Patrick KS, Zhu H .
3. Web site: Methylphenidate-based NPS: A review of the evidence of use and harm. . Advisory Council on the Misuse of Drugs . 31 March 2015 .
4. Florence Levy. Applications of pharmacogenetics in children with attention-deficit/hyperactivity disorder. Pharmgenomics Pers Med. July 2014. 349–356.