Isopropanol dehydrogenase (NADP+) explained

isopropanol dehydrogenase (NADP+)
Ec Number:	1.1.1.80
Cas Number:	37250-18-3
Go Code:	0050009

In enzymology, an isopropanol dehydrogenase (NADP⁺) is an enzyme that catalyzes the chemical reaction

propan-2-ol + NADP⁺

\rightleftharpoons acetone + NADPH + H⁺

Thus, the two substrates of this enzyme are propan-2-ol and NADP⁺, whereas its 3 products are acetone, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is propan-2-ol:NADP⁺ oxidoreductase. This enzyme is also called isopropanol dehydrogenase (NADP⁺). This enzyme participates in propanoate metabolism.

References

• Hoshino K . 1960 . Organism producing isopropanol from acetone. V. Enzymological [studies] on the oxidation-reduction of Lactobacillus brevis var. hofuensis . Japanese . Nippon Nogeikagaku Kaishi . 34 . 608 - 615 . 10.1271/nogeikagaku1924.34.7_608 . free .
• Hoshino K, Udagawa K . 1960 . Organism producing isopropanol from acetone. VI. Isopropanol dehydrogenase and alcohol dehydrogenase of Lactobacillus brevis var. hofuensis . Japanese . Nippon Nogeikagaku Kaishi . 34 . 616 - 619 . 10.1271/nogeikagaku1924.34.7_616 . free .