Isopentenyl phosphate kinase explained

Isopentenyl phosphate kinase
Ec Number:	2.7.4.26

Isopentenyl phosphate kinase is an enzyme with systematic name ATP:isopentenyl phosphate phosphotransferase.^{[1] [2] [3] [4]} This enzyme catalyses the following chemical reaction

\rightleftharpoons ADP + isopentenyl diphosphate

This enzyme takes part in the mevalonate pathway in Archaea.

Notes and References

1. Grochowski LL, Xu H, White RH . Methanocaldococcus jannaschii uses a modified mevalonate pathway for biosynthesis of isopentenyl diphosphate . Journal of Bacteriology . 188 . 9 . 3192–8 . May 2006 . 16621811 . 1447442 . 10.1128/JB.188.9.3192-3198.2006 .
2. Lange BM, Croteau R . Isopentenyl diphosphate biosynthesis via a mevalonate-independent pathway: isopentenyl monophosphate kinase catalyzes the terminal enzymatic step . Proceedings of the National Academy of Sciences of the United States of America . 96 . 24 . 13714–9 . November 1999 . 10570138 . 24130 . 10.1073/pnas.96.24.13714 . free .
3. Chen M, Poulter CD . Characterization of thermophilic archaeal isopentenyl phosphate kinases . Biochemistry . 49 . 1 . 207–17 . January 2010 . 19928876 . 3856865 . 10.1021/bi9017957 .
4. Mabanglo MF, Schubert HL, Chen M, Hill CP, Poulter CD . X-ray structures of isopentenyl phosphate kinase . ACS Chemical Biology . 5 . 5 . 517–27 . May 2010 . 20402538 . 2879073 . 10.1021/cb100032g .