Isonocardicin synthase explained

isonocardicin synthase
Ec Number:	2.5.1.38
Cas Number:	118246-74-5
Go Code:	0050007

In enzymology, an isonocardicin synthase is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + nocardicin E

\rightleftharpoons 5'-methylthioadenosine + isonocardicin A

Thus, the two substrates of this enzyme are S-adenosyl-L-methionine and nocardicin E, whereas its two products are 5'-methylthioadenosine and isonocardicin A.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is S-adenosyl-L-methionine:nocardicin-E 3-amino-3-carboxypropyltransferase. This enzyme is also called nocardicin aminocarboxypropyltransferase.

References

• Wilson BA, Bantia S, Salituro GM, Reeve AM, Townsend CA . 1988 . Cell-free biosynthesis of nocardicin A from nocardicin E and S-adenosylmethionine . J. Am. Chem. Soc. . 110 . 24 . 8238 - 8239 . 10.1021/ja00232a047 .