Isoliquiritigenin 2'-O-methyltransferase explained

Isoliquiritigenin 2'-O-methyltransferase
Ec Number:	2.1.1.154
Cas Number:	139317-14-9

In enzymology, an isoliquiritigenin 2'-O-methyltransferase is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + isoliquiritigenin

\rightleftharpoons S-adenosyl-L-homocysteine + 2'-O-methylisoliquiritigenin

Thus, the two substrates of this enzyme are S-adenosyl methionine and isoliquiritigenin, whereas its two products are S-adenosylhomocysteine and 2'-O-methylisoliquiritigenin.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:isoliquiritigenin 2'-O-methyltransferase. Other names in common use include chalcone OMT, and CHMT.

References

• Maxwell CA, Edwards R, Dixon RA . 1992 . Identification, purification, and characterization of S-adenosyl-L-methionine: isoliquiritigenin 2'-O-methyltransferase from alfalfa (Medicago sativa L.) . Arch. Biochem. Biophys. . 293 . 158 - 66 . 1731632 . 10.1016/0003-9861(92)90379-B . 1 .
• Ichimura M, Furuno T, Takahashi T, Dixon RA, Ayabe S . 1997 . Enzymic O-methylation of isoliquiritigenin and licodione in alfalfa and licorice cultures . . 44 . 991 - 5 . 9055445 . 10.1016/S0031-9422(96)00670-X . 6 .