Isofuran Explained

Isofurans are nonclassic eicosanoids formed nonenzymatically by free radical mediated peroxidation of arachidonic acid. The isofurans are similar to the isoprostanes and are formed under similar conditions, but contain a substituted tetrahydrofuran ring. The concentration of oxygen affects this process; at elevated oxygen concentrations, the formation of isofurans is favored whereas the formation of isoprostanes is disfavored.[1] [2]

References

  1. Roberts. L. Jackson. Fessel. Joshua P.. Davies. Sean S.. 2006-04-05. The Biochemistry of the Isoprostane, Neuroprostane, and Isofuran Pathways of Lipid Peroxidation. Brain Pathology. en. 15. 2. 143–148. 10.1111/j.1750-3639.2005.tb00511.x. 15912887. 1015-6305. 8095955.
  2. Roberts, LJ 2nd and Fessel, JP. Mar 2004. The biochemistry of the isoprostane, neuroprostane, and isofuran pathways of lipid peroxidation.. Chem Phys Lipids. 128. 1–2. 173–86. 10.1016/j.chemphyslip.2003.09.016. 15037162.

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