Isocytosine Explained

Isocytosine or 2-aminouracil is a pyrimidine base that is an isomer of cytosine. It is used in combination with isoguanine in studies of unnatural nucleic acid analogues of the normal base pairs in DNA.[1] In particular, it is used as a nucleobase of hachimoji RNA.[2]

It can be synthesized from guanidine and malic acid.[3]

It is also used in physical chemical studies involving metal complex binding, hydrogen bonding, and tautomerism and proton transfer effects in nucleobases.[4]

Notes and References

  1. Web site: Isocytosine . Molecule of the Week . November 1, 2012 . American Chemical Society.
  2. Hoshika. Shuichi. etal. 22 February 2019. Hachimoji DNA and RNA: A genetic system with eight building blocks . Science. 363. 6429. 884-887. 10.1126/science.aat0971. 30792304. 6413494.
  3. A New Synthesis of Isocytosine . William T. Caldwell, Harry B. Kime . J. Am. Chem. Soc. . 1940 . 62 . 9 . 2365–2365 . 10.1021/ja01866a028.
  4. Web site: Isocytosine . November 1, 2012 . Sigma-Aldrich.

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