Isoconazole Explained

Iupac Name:	(RS)-1-[2-[(2,6-Dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
Cas Number:	27523-40-6
Atc Prefix:	D01
Atc Suffix:	AC05
Pubchem:	3760
Drugbank:	DB08943
Chembl:	1571863
Chemspiderid:	3629
Unii:	GRI7WFR424
Kegg:	D04624
Chebi:	82865
C:	18
H:	14
Cl:	4
N:	2
O:	1
Smiles:	Clc1ccc(c(Cl)c1)C(OCc2c(Cl)cccc2Cl)Cn3ccnc3

Isoconazole is an azole antifungal drug and could inhibit gram positive bacteria.^{[1] [2]} For foot and vaginal infections, isoconazole has a similar effectiveness to clotrimazole.^{[3] [4]} Isoconazole nitrate may be used in combination with corticosteroid diflucortolone to increase its bioavailability.^[1]

It was patented in 1968 and approved for medical use in 1979.^[5]

Notes and References

1. Veraldi S . Isoconazole nitrate: a unique broad-spectrum antimicrobial azole effective in the treatment of dermatomycoses, both as monotherapy and in combination with corticosteroids . Mycoses . 56 . Suppl 1 . 3–15 . May 2013 . 23574019 . 10.1111/myc.12054 . 1881151 .
2. Book: . Isoconazole . 12th . 5176 . 0-911910-12-3 . Budavari S . 1996 . Budavari S, O'Neil M, Smith A, Heckelman P, Obenchain J .
3. Oyeka CA, Gugnani HC . Isoconazole nitrate versus clotrimazole in foot and nail infections due to Hendersonula toruloidea, Scytalidium hyalinum and dermatophytes . Mycoses . 35 . 11–12 . 357–361 . 1992 . 1302811 . 10.1111/j.1439-0507.1992.tb00894.x . 6764090 .
4. Cohen L . Single dose treatment of vaginal candidosis: comparison of clotrimazole and isoconazole . The British Journal of Venereal Diseases . 60 . 1 . 42–44 . February 1984 . 6365236 . 1046268 . 10.1136/sti.60.1.42 .
5. Book: Fischer J, Ganellin CR . C. Robin Ganellin . 2006 . Analogue-based Drug Discovery . en . John Wiley & Sons . 9783527607495 . 502 .