3-Iodothyronamine Explained
3-Iodothyronamine (T1AM) is an endogenous thyronamine. T1AM is a high-affinity ligand for the trace amine-associated receptor TAAR1 (TAR1, TA1), a recently discovered G protein-coupled receptor.[1] [2] T1AM is the most potent endogenous TAAR1 agonist yet discovered.[3] Activation of TAAR1 by T1AM results in the production of large amounts of cAMP. This effect is coupled with decreased body temperature and cardiac output.[4] Wu et al. have pointed out that this relationship is not typical of the endocrine system, indicating that TAAR1 activity may not be coupled to G-proteins in some tissues, or that T1AM may interact with other receptor subtypes.[3]
T1AM may be part of a signaling pathway to modulate cardiac function, as the compound can induce negative inotropic effects and decrease cardiac output.[5]
See also
Notes and References
- Scanlan T, Suchland K, Hart M, Chiellini G, Huang Y, Kruzich P, Frascarelli S, Crossley D, Bunzow J, Ronca-Testoni S, Lin E, Hatton D, Zucchi R, Grandy D . 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone . Nat. Med. . 10 . 6 . 638–42 . 2004 . 15146179 . 10.1038/nm1051. 2389946 .
- Hart M, Suchland K, Miyakawa M, Bunzow J, Grandy D, Scanlan T . Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues . J. Med. Chem. . 49 . 3 . 1101–12 . 2006 . 16451074 . 10.1021/jm0505718.
- Wu SY, Green WL, Huang WS, Hays MT, Chopra IJ . 10.1089/thy.2005.15.943 . Alternate Pathways of Thyroid Hormone Metabolism . Thyroid . 15 . 8 . 943–958 . 2005 . 16131336.
- Web site: New compound may act to keep thyroid activity in check . 2008-05-30.
- Chiellini G, Frascarelli S, Ghelardoni S, Carnicelli V, Tobias SC, Debarber A, Brogioni S, Ronca-Testoni S, Cerbai E, Grandy DK, Scanlan TS, Zucchi R . Cardiac effects of 3-iodothyronamine: a new aminergic system modulating cardiac function . The FASEB Journal. 21. 7. 1597–608. 2007 . 17284482 . 10.1096/fj.06-7474com. free . 14015560 .
