Diiodohydroxyquinoline Explained

The quinoline derivative diiodohydroxyquinoline (INN), or iodoquinol (USAN), brand name Diodoquin, can be used in the treatment of amoebiasis.^[1]

It is poorly absorbed from the gastrointestinal tract and is used as a luminal amebicide. It acts by chelation of ferrous ions essential for metabolism.^[2]

It was discovered by Adco Co. and introduced as diiodohydroxyquinoline.^[3]

Susceptibility of Dientamoeba fragilis has been measured.^[4]

Iodoquinol is an amebicide used against Entamoeba histolytica, and it is active against both cyst and trophozoites that are localized in the lumen of the intestine. It is considered the drug of choice for treating asymptomatic or moderate forms of amebiasis. The full mechanism of action is unknown. Iodoquinol is used for diseases caused by moderate intestinal amebiasis.

Diiodohydroxyquinoline enhances zinc absorption in the zinc deficiency disorder acrodermatitis enteropathica, probably because it acts as a zinc ionophore.^[5]

See also

• Ionophore

Notes and References

1. Ghaskadbi S, Vaidya VG . In vivo antimutagenic effect of ascorbic acid against mutagenicity of the common antiamebic drug diiodohydroxyquinoline . Mutat. Res. . 222 . 3 . 219–22 . March 1989 . 2493578 . 10.1016/0165-1218(89)90137-7.
2. Nagata. Noriyuki. Marriott. Deborah. Harkness. John. Ellis. John T.. Stark. Damien. Current treatment options for Dientamoeba fragilis infections. International Journal for Parasitology: Drugs and Drug Resistance. 2. 2012. 204–215. 2211-3207. 10.1016/j.ijpddr.2012.08.002. 3862407. 24533282.
3. Book: Publishing, William Andrew. Pharmaceutical Manufacturing Encyclopedia. 3rd. 2013-01-15. Elsevier Science. 9780080947266. 1312. en.
4. Chan FT, Guan MX, Mackenzie AM, Diaz-Mitoma F . Susceptibility testing of Dientamoeba fragilis ATCC 30948 with iodoquinol, paromomycin, tetracycline, and metronidazole . Antimicrob. Agents Chemother. . 38 . 5 . 1157–60 . May 1994 . 8067755 . 188168 . 10.1128/aac.38.5.1157.
5. Aggett . P.J. . Delves . H.T. . Harries . J.T. . Bangham . A.D. . The possible role of Diodoquin as a zinc ionophore in the treatment of acrodermatitis enteropathica . Biochemical and Biophysical Research Communications . March 1979 . 87 . 2 . 513–517 . 10.1016/0006-291X(79)91825-4. 375935 .